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Relevant Background Publications by Team Members

These publications, co-authored by project team members, address diagnostic delay, the need for rapid non-sputum-based TB tests, and the molecular epidemiology and characterization of Mycobacterium tuberculosis, and provide background information for the SeroSelectTB project.

Yimer SHolm-Hansen C, Yimaldu T, Bjune G. Evaluating an active case-finding strategy to identify smear-positive tuberculosis in rural Ethiopia. IJTLD 2009;13(11):1399-1404.å


Yimer SHolm-Hansen C, Yimaldu T, Bjune G. Health care seeking among pulmonary tuberculosis suspects and patients in rural Ethiopia: a community-based study. BMC Public Health 2009;454. doi:10.1186/1471-2458-9-454


Yimer SHolm-Hansen C, Bjune G. The perspective of private practitioners regarding tuberculosis case detection and treatment delay in Amhara Region, Ethiopia: a cross-sectional study. BMC Res Notes 2011;4:285.  doi:10.1186/1756-0500-4-285


Holm-Hansen CYimer S, Ihle Ø, Korsvold GE, Oftung F, Michaelsen TE, Haneberg B and the ”TBRT Consortium”. Development of a rapid serological screening test for TB. In: Strengthening Research Partnerships for Better Health and Sustainable Development. Abstracts of the Sixth EDCTP Forum, 9-12 October 2011, Addis Ababa, Ethiopia. Trop Med Int Health 2012;17:Issue Supplement s1,1-82.


Yimer SA, Hailu E, Derese Y, Bjune GA, Holm-Hansen C. Molecular epidemiology of Mycobacterium tuberculosis isolates among pulmonary tuberculosis patients in Amhara Region, Ethiopia. APMIS 2013;121(9):878-85.


Yimer SAHolm-Hansen C, Storla DG, Bjune GA. Tuberculosis management time; an alternative parameter for measuring the tuberculosis infectious pool. Trop Med Int Health 2014;19(3):313-20.


Yimer SA, Bjune GA, Holm-Hansen C. Time to first consultation, diagnosis and treatment of TB among patients attending a referral hospital in Northwest, Ethiopia. BMC Infect Dis 2014;14:19. doi:10.1186/1471-2334-14-19


Yimer SA, Norheim G, Namouchi A, Zegeye ED, Kinander W, Tønjum T, Bekele S, Mannsåker T, Bjune G, Aseffa A, Holm-Hansen C. Mycobacterium tuberculosis lineage 7 strains are associated with prolonged patient delay in seeking treatment for pulmonary tuberculosis in Amhara Region, Ethiopia. J Clin Microbiol 2015;53(4):1301-1309.


Nebenzahl-Guimaraes H, Yimer SAHolm-Hansen C, de Beer J, Brosch R, van Soolingen D. Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: "Aethiops vetus".

Microb Genom 2016. doi: 10.1099/mgen.0.000063


Gebreegziabher SB, Bjune GA, Yimer SA. Total Delay Is Associated with Unfavorable Treatment Outcome among Pulmonary Tuberculosis Patients in West Gojjam Zone, Northwest Ethiopia: A Prospective Cohort Study. PLOS ONE 2016;11(7):e0159579.


Yimer SA, Namouchi A, Zegeye ED, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønum T. Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7. BMC Evol Biol 2016;16:146. doi: 10.1186/s12862-016-0715-z

Naidoo P, Theron G, Rangaka MX, Chihota VN, Vaughan L, Brey ZO, Pillay Y. The South African tuberculosis care cascade: estimated losses and methodological challenges. J Infect Dis 2017, 216(suppl_7), S702-S713. doi: 10.1093/infdis/jix335

Yimer SA, Birhanu AG, Kalayou S, Riaz T, Zegeye ED, Beyene GB, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T. Comparative proteomic analysis of Mycobacterium tuberculosis lineage 7 and lineage 4 reveals differentially abundant proteins linked to slow growth and virulence. Front Microbiol 2017;8:795. doi: 10.3389/fmicb.2017.00795


Birhanu AG, Yimer SAHolm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T. Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 strains: proteins involved in bioenergetics, virulence and antimicrobial resistance are acetylated. J Proteome Res 2017;16(11):4045-4059. doi: 10.1021/acs.jproteome.7b00429. Epub 2017 Oct 4.


Borain N, Petersen L, Du Plessis JTheron GHolm-Hansen C. A rapid serological triage test for detecting active tuberculosis. BMJ Global Health 2017;2:A35. doi: 10.1136/bmjgh-2016-000260.91

García-Basteiro AL, DiNardo A, Saavedra B, Silva DR, Palmero D, Gegia M, Migliori GB, Duarte R, Mambuque E, Centis R, Cuevas LE, Izco S, Theron G. Point of care diagnostics for tuberculosis. Pulmonology 2018, 24(2), 73-85. doi: 10.1016/j.rppnen.2017.12.002

Birhanu AG, Yimer SA, Kalayou S, Riaz T, Zegeye ED, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T. Ample glycosylation in membrane and cell envelope protein may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex. Sci Rep 2019;9:2927.


Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D, Dheda K. Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation. Lancet Glob Health 2019, 7(6), e798-e807. doi: 10.1016/S2214-109X(19)30164-0

Yimer SA, Kalayou S, Homberset H, Birhanua AG, Riaz T, Zegeye ED, Lutter T, Abebe M, Holm-Hansen C, Aseffa A, Tønjum T. Lineage-specific proteomic signatures in the Mycobacterium tuberculosis complex reveal differential abundance of proteins involved in virulence, DNA repair, CRISPR-Cas, bioenergetics and lipid metabolism. Front Microbiol (section Evolutionary and Genomic Microbiology) 2020;11.

Mishra H, Reeve BW, Palmer Z, Caldwell J, Dolby T, Naidoo CC, Jackson GJ, Schumacher SG, Denkinger CM, Diacon AH, van Helden PD, Marx FM, Warren RMTheron, G. Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. Lancet Respir Med 2020, 8(4), 368-382. doi: 10.1016/S2213-2600(19)30370-4


Turner CT, Gupta RK, Tsaliki E, Roe JK, Mondal P, Nyawo GR, Palmer Z, Miller RF, Reeve BW, Theron G, Noursadeghi M. Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study. Lancet Respir Med 2020, 8(4), 407-419. doi: 10.1016/S2213-2600(19)30469-2

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